Varaico: Literature-Extracted Genetic Variants

GRM6

254 papers

RefSeq Summary

L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in mo...

Pfam Domains

ANF_receptoraa 67–478UCSCReceptor family ligand binding region

NCD3Gaa 513–564UCSCNine Cysteines Domain of family 3 GPCR

7tm_3aa 579–839UCSC7 transmembrane sweet-taste receptor of 3 GCPR

Gene Aliases

HGNC Name

glutamate metabotropic receptor 6

HGNC Alias Symbols

GPRC1F; mGlu6; MGLUR6; CSNB1B

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_000843.4

p.V594M

c.1780G>A

Surrounding Variants

2 papers

NM_000843.4

p.P589L

c.1766C>T

2 papers

NM_000843.4

p.P588L

c.1763C>T

3 papers

NM_000843.4

p.T600P

c.1798A>C

1 paper

NM_000843.4

p.A586E

c.1757C>A

1 paper

NM_000843.4

p.T602T

c.1806G>A

1 paper

NM_000843.4

p.R609W

c.1825C>T

4 papers

NM_000843.4

p.R578C

c.1732C>T

1 paper

NM_000843.4

p.N611S

c.1832A>G

1 paper

NM_000843.4

p.T613M

c.1838C>T

2 papers

NM_000843.4

p.N612_T613del1

c.1835_1837delTGT

1 paper

NM_000843.4

p.P614S

c.1840C>T

1 paper

NM_000843.4

p.R572C

c.1714C>T