Varaico: Literature-Extracted Genetic Variants

GRM6

254 papers

RefSeq Summary

L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in mo...

Pfam Domains

ANF_receptoraa 67–478UCSCReceptor family ligand binding region

NCD3Gaa 513–564UCSCNine Cysteines Domain of family 3 GPCR

7tm_3aa 579–839UCSC7 transmembrane sweet-taste receptor of 3 GCPR

Gene Aliases

HGNC Name

glutamate metabotropic receptor 6

HGNC Alias Symbols

GPRC1F; mGlu6; MGLUR6; CSNB1B

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_000843.4

p.R547H

c.1640G>A

Surrounding Variants

1 paper

NM_000843.4

p.R547C

c.1639C>T

1 paper

NM_000843.4

p.Q549R

c.1646A>G

1 paper

NM_000843.4

p.G545W

c.1633G>T

1 paper

NM_000843.4

p.R563M

c.1688G>T

1 paper

NM_000843.4

p.T565M

c.1694C>T

1 paper

NM_000843.4

p.P564_T565del1

c.1691_1693delTGG

3 papers

NM_000843.4

p.R527W

c.1579C>T

2 papers

NM_000843.4

p.P524L

c.1571C>T

1 paper

NM_000843.4

p.C571S

c.1711T>A

1 paper

NM_000843.4

p.C571F

c.1712G>T

1 paper

NM_000843.4

p.C571S

c.1712G>C

1 paper

NM_000843.4

p.G523insFs

c.1567_1568insCG