Varaico: Literature-Extracted Genetic Variants

GRM8

229 papers

RefSeq Summary

L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in mo...

Pfam Domains

ANF_receptoraa 74–479UCSCReceptor family ligand binding region

NCD3Gaa 511–562UCSCNine Cysteines Domain of family 3 GPCR

7tm_3aa 577–837UCSC7 transmembrane sweet-taste receptor of 3 GCPR

Gene Aliases

HGNC Name

glutamate metabotropic receptor 8

HGNC Alias Symbols

GLUR8; GPRC1H; mGlu8; MGLUR8

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_000845.3

p.E734*

c.2200G>T

Surrounding Variants

1 paper

NM_000845.3

p.A736V

c.2207C>T

1 paper

NM_000845.3

p.G738V

c.2213G>T

1 paper

NM_000845.3

p.R729Q

c.2186G>A

1 paper

NM_000845.3

p.R729W

c.2185C>T

1 paper

NM_000845.3

p.S745C

c.2234C>G

4 papers

NM_000845.3

p.H720fs

c.2158_2159fs

3 papers

NM_000845.3

p.H720insFs

c.2158dupC

4 papers

NM_000845.3

p.H720delFs

c.2158delG

2 papers

NM_000845.3

p.H720fs

c.2158_2159fs

1 paper

NM_000845.3

p.P719fs

c.2155_2156fs

1 paper

NM_000845.3

p.P718L

c.2153C>T

1 paper

NM_000845.3

p.D717H

c.2149G>C