Varaico: Literature-Extracted Genetic Variants

GRM8

229 papers

RefSeq Summary

L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in mo...

Pfam Domains

ANF_receptoraa 74–479UCSCReceptor family ligand binding region

NCD3Gaa 511–562UCSCNine Cysteines Domain of family 3 GPCR

7tm_3aa 577–837UCSC7 transmembrane sweet-taste receptor of 3 GCPR

Gene Aliases

HGNC Name

glutamate metabotropic receptor 8

HGNC Alias Symbols

GLUR8; GPRC1H; mGlu8; MGLUR8

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_000845.3

p.S683Y

c.2048C>A

Surrounding Variants

2 papers

NM_000845.3

p.S683A

c.2047T>G

2 papers

NM_000845.3

p.V684A

c.2051T>C

2 papers

NM_000845.3

p.T685A

c.2053A>G

2 papers

NM_000845.3

p.G680A

c.2039G>C

2 papers

NM_000845.3

p.A686V

c.2057C>T

2 papers

NM_000845.3

p.A686G

c.2057C>G

1 paper

NM_000845.3

p.P687S

c.2059C>T

2 papers

NM_000845.3

p.P687A

c.2059C>G

2 papers

NM_000845.3

p.E678A

c.2033A>C

1 paper

NM_000845.3

p.I676M

c.2028A>G

1 paper

NM_000845.3

p.I676L

c.2026A>T

1 paper

NM_000845.3

p.I676L

c.2026A>C