Varaico: Literature-Extracted Genetic Variants

GRM8

229 papers

RefSeq Summary

L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in mo...

Pfam Domains

ANF_receptoraa 74–479UCSCReceptor family ligand binding region

NCD3Gaa 511–562UCSCNine Cysteines Domain of family 3 GPCR

7tm_3aa 577–837UCSC7 transmembrane sweet-taste receptor of 3 GCPR

Gene Aliases

HGNC Name

glutamate metabotropic receptor 8

HGNC Alias Symbols

GLUR8; GPRC1H; mGlu8; MGLUR8

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_000845.3

p.H32_E35delFs

c.94_104del11

Surrounding Variants

1 paper

NM_000845.3

p.Y36H

c.106T>C

1 paper

NM_000845.3

p.Y36N

c.106T>A

1 paper

NM_000845.3

p.Q34K

c.100C>A

1 paper

NM_000845.3

p.H38fs

c.112_113fs

1 paper

NM_000845.3

p.H38Y

c.112C>T

1 paper

NM_000845.3

p.H38delFs

c.112delG

1 paper

NM_000845.3

p.R41P

c.122G>C

2 papers

NM_000845.3

p.R41Q

c.122G>A

1 paper

NM_000845.3

p.V42G

c.125T>G

1 paper

NM_000845.3

p.W23C

c.69G>T

1 paper

NM_000845.3

p.W23C

c.69G>C

2 papers

NM_000845.3

p.L48*

c.143T>A