gamma-secretase activating protein

PION

LOC54103

pigeon homolog (Drosophila)

Gamma-secretase-activating protein

Protein pigeon homolog

Gamma-secretase-activating protein 16 kDa C-terminal form

GSAP-16K

gamma-Secretase-activating protein C-term

Accumulation of neurotoxic amyloid-beta is a major hallmark of Alzheimer disease (AD; MIM 104300). Formation of amyloid-beta is catalyzed by gamma-secretase (see PSEN1; MIM 104311), a protease with numerous substrates. PION, or GSAP, selectively increases amyloid-beta production through a mechanism involving its interaction with both gamma-secretase and its substrate, the amyloid-beta precursor protein (APP; MIM 104760) C-terminal fragment (APP-CTF) (He et al., 2010 [PubMed 20811458]).[supplied by OMIM, Nov 2010].

Varaico: Literature-Extracted Genetic Variants

GSAP

RefSeq Summary

Pfam Domains

Gene Aliases

HGNC Name

HGNC Previous Symbol