Varaico: Literature-Extracted Genetic Variants

HCN1

326 papers

RefSeq Summary

The membrane protein encoded by this gene is a hyperpolarization-activated cation channel that contributes to the native pacemaker currents in heart and neurons. The encoded protein can homodimerize o...

Pfam Domains

Ion_trans_Naa 98–141UCSCIon transport protein N-terminal

Ion_transaa 142–405UCSCIon transport protein

cNMP_bindingaa 493–576UCSCCyclic nucleotide-binding domain

Gene Aliases

HGNC Name

hyperpolarization activated cyclic nucleotide gated potassium channel 1

HGNC Previous Symbol

BCNG1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

3 papers

NM_021072.4

p.Y289D

c.865T>G

Surrounding Variants

1 paper

NM_021072.4

p.Y289F

c.866A>T

1 paper

NM_021072.4

p.T288P

c.862A>C

1 paper

NM_021072.4

p.H286N

c.856C>A

1 paper

NM_021072.4

p.F285L

c.855C>G

1 paper

NM_021072.4

p.F285L

c.855C>A

1 paper

NM_021072.4

p.F285L

c.853T>C

10 papers

NM_021072.4

p.R297T

c.890G>C

1 paper

NM_021072.4

p.R297K

c.890G>A

1 paper

NM_021072.4

p.G303C

c.907G>T

21 papers

NM_021072.4

p.M305L

c.913A>T

21 papers

NM_021072.4

p.M305L

c.913A>C

1 paper

NM_021072.4

p.M305R

c.914T>G