Varaico: Literature-Extracted Genetic Variants

Gene:HCRTR1
Variant:p.L300M

HCRTR1

79 papers

RefSeq Summary

The protein encoded by this gene is a G-protein coupled receptor involved in the regulation of feeding behavior. The encoded protein selectively binds the hypothalamic neuropeptide orexin A. A related...

Pfam Domains

7tm_1aa 63–358UCSC7 transmembrane receptor (rhodopsin family)

Gene Aliases

HGNC Name

hypocretin receptor 1

HGNC Alias Symbols

OX1R; ORXR1

Papers
RefSeq ID
Protein change
DNA change
Selected Variant
1 paper
NM_001525.3
p.L300M
c.898C>A
Surrounding Variants
1 paper
NM_001525.3
p.M301K
c.902T>A
1 paper
NM_001525.3
p.K298E
c.892A>G
1 paper
NM_001525.3
p.V302M
c.904G>A
1 paper
NM_001525.3
p.A297D
c.890C>A
1 paper
NM_001525.3
p.V303M
c.907G>A
1 paper
NM_001525.3
p.V306G
c.917T>G
1 paper
NM_001525.3
p.R293Q
c.878G>A
1 paper
NM_001525.3
p.R293W
c.877C>T
2 papers
NM_001525.3
p.A308T
c.922G>A
1 paper
NM_001525.3
p.R291H
c.872G>A
1 paper
NM_001525.3
p.R291C
c.871C>T
1 paper
NM_001525.3
p.M290I
c.870G>A
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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."