Varaico: Literature-Extracted Genetic Variants

HDAC6

432 papers

RefSeq Summary

Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription f...

Pfam Domains

Hist_deacetylaa 105–402UCSCHistone deacetylase domain

Hist_deacetylaa 500–798UCSCHistone deacetylase domain

zf-UBPaa 1133–1195UCSCZn-finger in ubiquitin-hydrolases and other protein

Gene Aliases

HGNC Name

histone deacetylase 6

HGNC Alias Symbols

KIAA0901; JM21; HD6; FLJ16239; PPP1R90; KDAC6

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_006044.4

p.M142V

c.424A>G

Surrounding Variants

1 paper

NM_006044.4

p.L141L

c.423G>C

1 paper

NM_006044.4

p.R134W

c.400C>T

1 paper

NM_006044.4

p.Q132Q

c.396G>A

1 paper

NM_006044.4

p.C128S

c.383G>C

1 paper

NM_006044.4

p.C128S

c.382T>A

1 paper

NM_006044.4

p.R127L

c.380G>T

1 paper

NM_006044.4

p.R127S

c.379C>A

2 papers

NM_006044.4

p.I120F

c.358A>T

3 papers

NM_006044.4

p.K116N

c.348G>C

2 papers

NM_006044.4

p.K116R

c.347A>G

1 paper

NM_006044.4

p.R111Q

c.332G>A

4 papers

NM_006044.4

p.E107E

c.321A>G