Varaico: Literature-Extracted Genetic Variants

HDAC6

432 papers

RefSeq Summary

Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription f...

Pfam Domains

Hist_deacetylaa 105–402UCSCHistone deacetylase domain

Hist_deacetylaa 500–798UCSCHistone deacetylase domain

zf-UBPaa 1133–1195UCSCZn-finger in ubiquitin-hydrolases and other protein

Gene Aliases

HGNC Name

histone deacetylase 6

HGNC Alias Symbols

KIAA0901; JM21; HD6; FLJ16239; PPP1R90; KDAC6

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_006044.4

p.R165H

c.494G>A

Surrounding Variants

1 paper

NM_006044.4

p.V166A

c.497T>C

3 papers

NM_006044.4

p.D169G

c.506A>G

1 paper

NM_006044.4

p.T170A

c.508A>G

1 paper

NM_006044.4

p.Y171Y

c.513C>T

1 paper

NM_006044.4

p.S188*

c.563C>A

1 paper

NM_006044.4

p.S188*

c.563C>G

1 paper

NM_006044.4

p.R193K

c.578G>A

1 paper

NM_006044.4

p.R193R

c.579G>A

2 papers

NM_006044.4

p.A197V

c.590C>T

1 paper

NM_006044.4

p.M142V

c.424A>G

1 paper

NM_006044.4

p.L141L

c.423G>C

1 paper

NM_006044.4

p.R134W

c.400C>T