Varaico: Literature-Extracted Genetic Variants

Gene:HDAC8
Variant:p.A188T

HDAC8

207 papers

RefSeq Summary

Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription f...

Pfam Domains

Hist_deacetylaa 32–189UCSCHistone deacetylase domain
Hist_deacetylaa 184–296UCSCHistone deacetylase domain

Gene Aliases

HGNC Name

histone deacetylase 8

HGNC Previous Symbols

HDACL1; WTS; MRXS6

Papers
RefSeq ID
Protein change
DNA change
Selected Variant
13 papers
NM_018486.3
p.A188T
c.562G>A
Surrounding Variants
4 papers
NM_018486.3
p.E186K
c.556G>A
1 paper
NM_018486.3
p.G184D
c.551G>A
2 papers
NM_018486.3
p.V195G
c.584T>G
2 papers
NM_018486.3
p.V195D
c.584T>A
2 papers
NM_018486.3
p.M196L
c.586A>T
1 paper
NM_018486.3
p.M196T
c.587T>C
2 papers
NM_018486.3
p.M196K
c.587T>A
2 papers
NM_018486.3
p.S199T
c.595T>A
1 paper
NM_018486.3
p.S199F
c.596C>T
1 paper
NM_018486.3
p.L200P
c.599T>C
2 papers
NM_018486.3
p.H201Y
c.601C>T
1 paper
NM_018486.3
p.K202E
c.604A>G
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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."