histone deacetylase 9

KIAA0744

MITR

HDAC7B

Histone deacetylase 9

Histone deacetylase 7B

Histone deacetylase-related protein

MEF2-interacting transcription repressor MITR

HD7b

Glutamine rich N terminal domain of histone deacetylase 4

Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene has sequence homology to members of the histone deacetylase family. This gene is orthologous to the Xenopus and mouse MITR genes. The MITR protein lacks the histone deacetylase catalytic domain. It represses MEF2 activity through recruitment of multicomponent corepressor complexes that include CtBP and HDACs. This encoded protein may play a role in hematopoiesis. Multiple alternatively spliced transcripts have been described for this gene but the full-length nature of some of them has not been determined. [provided by RefSeq, Jul 2008].

Varaico: Literature-Extracted Genetic Variants

HDAC9

RefSeq Summary

Pfam Domains

Gene Aliases

HGNC Name

HGNC Alias Symbols