HECT and RLD domain containing E3 ubiquitin protein ligase 4

DKFZP564G092

KIAA1593

hect domain and RLD 4

Probable E3 ubiquitin-protein ligase HERC4

HECT domain and RCC1-like domain-containing protein 4

HECT-type E3 ubiquitin transferase HERC4

HERC4 belongs to the HERC family of ubiquitin ligases, all of which contain a HECT domain and at least 1 RCC1 (MIM 179710)-like domain (RLD). The 350-amino acid HECT domain is predicted to catalyze the formation of a thioester with ubiquitin before transferring it to a substrate, and the RLD is predicted to act as a guanine nucleotide exchange factor for small G proteins (Hochrainer et al., 2005 [PubMed 15676274]).[supplied by OMIM, Mar 2008].

Varaico: Literature-Extracted Genetic Variants

HERC4

RefSeq Summary

Pfam Domains

Gene Aliases

HGNC Name

HGNC Alias Symbols