Varaico: Literature-Extracted Genetic Variants

Gene:ICOS
Variant:p.Y28*

ICOS

156 papers

RefSeq Summary

The protein encoded by this gene belongs to the CD28 and CTLA-4 cell-surface receptor family. It forms homodimers and plays an important role in cell-cell signaling, immune responses, and regulation o...

Pfam Domains

V-set_2aa 23–134UCSCICOS V-set domain

Gene Aliases

HGNC Name

inducible T cell costimulator

HGNC Alias Symbols

AILIM; CD278

Papers
RefSeq ID
Protein change
DNA change
Selected Variant
1 paper
NM_012092.4
p.Y28*
c.84T>A
Surrounding Variants
1 paper
NM_012092.4
p.Y28*
c.84T>G
1 paper
NM_012092.4
p.M30fs
c.88_89fs
3 papers
NM_012092.4
p.M30delFs
c.90delG
1 paper
NM_012092.4
p.G24A
c.71G>C
1 paper
NM_012092.4
p.G24V
c.71G>T
1 paper
NM_012092.4
p.C42W
c.126C>G
1 paper
NM_012092.4
p.D46D
c.138C>T
1 paper
NM_012092.4
p.F51S
c.152T>C
2 papers
NM_012092.4
p.G59insFs
c.177dupG
1 paper
NM_012092.4
p.G58R
c.172G>A
1 paper
NM_012092.4
p.G58R
c.172G>C
1 paper
NM_012092.4
p.G58E
c.173G>A
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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."