Varaico: Literature-Extracted Genetic Variants

Gene:ICOS
Variant:p.K78N

ICOS

156 papers

RefSeq Summary

The protein encoded by this gene belongs to the CD28 and CTLA-4 cell-surface receptor family. It forms homodimers and plays an important role in cell-cell signaling, immune responses, and regulation o...

Pfam Domains

V-set_2aa 23–134UCSCICOS V-set domain

Gene Aliases

HGNC Name

inducible T cell costimulator

HGNC Alias Symbols

AILIM; CD278

Papers
RefSeq ID
Protein change
DNA change
Selected Variant
1 paper
NM_012092.4
p.K78N
c.234G>T
Surrounding Variants
1 paper
NM_012092.4
p.K78N
c.234G>C
1 paper
NM_012092.4
p.S76F
c.227C>T
1 paper
NM_012092.4
p.S76P
c.226T>C
1 paper
NM_012092.4
p.V75M
c.223G>A
1 paper
NM_012092.4
p.C83Y
c.248G>A
1 paper
NM_012092.4
p.C83*
c.249C>A
1 paper
NM_012092.4
p.N73Y
c.217A>T
1 paper
NM_012092.4
p.S85P
c.253T>C
1 paper
NM_012092.4
p.G70R
c.208G>A
1 paper
NM_012092.4
p.G70R
c.208G>C
1 paper
NM_012092.4
p.K69R
c.206A>G
2 papers
NM_012092.4
p.T68_K69insFs
c.204_205insA
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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."