Varaico: Literature-Extracted Genetic Variants

Gene:ICOS
Variant:p.G125R

ICOS

156 papers

RefSeq Summary

The protein encoded by this gene belongs to the CD28 and CTLA-4 cell-surface receptor family. It forms homodimers and plays an important role in cell-cell signaling, immune responses, and regulation o...

Pfam Domains

V-set_2aa 23–134UCSCICOS V-set domain

Gene Aliases

HGNC Name

inducible T cell costimulator

HGNC Alias Symbols

AILIM; CD278

Papers
RefSeq ID
Protein change
DNA change
Selected Variant
1 paper
NM_012092.4
p.G125R
c.373G>C
Surrounding Variants
1 paper
NM_012092.4
p.G125R
c.373G>A
1 paper
NM_012092.4
p.T124T
c.372A>G
1 paper
NM_012092.4
p.T124P
c.370A>C
3 papers
NM_012092.4
p.F119S
c.356T>C
1 paper
NM_012092.4
p.E132Splc
c.394+2T>A
1 paper
NM_012092.4
p.P117A
c.349C>G
1 paper
NM_012092.4
p.P117S
c.349C>T
1 paper
NM_012092.4
p.P116H
c.347C>A
1 paper
NM_012092.4
p.P116S
c.346C>T
1 paper
NM_012092.4
p.F114S
c.341T>C
1 paper
NM_012092.4
p.F114V
c.340T>G
4 papers
NM_012092.4
p.F108_L111delFs
c.323_332del10
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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."