Varaico: Literature-Extracted Genetic Variants

Gene:IDH2
Variant:p.I157T

IDH2

2,456 papers

RefSeq Summary

Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor...

Pfam Domains

Iso_dhaa 45–441UCSCIsocitrate/isopropylmalate dehydrogenase

Gene Aliases

HGNC Name

isocitrate dehydrogenase (NADP(+)) 2

HGNC Alias Symbol

IDH-2

Papers
RefSeq ID
Protein change
DNA change
Selected Variant
2 papers
NM_002168.4
p.I157T
c.470T>C
Surrounding Variants
3 papers
NM_002168.4
p.P158S
c.472C>T
2 papers
NM_002168.4
p.P158T
c.472C>A
2 papers
NM_002168.4
p.P158L
c.473C>T
2 papers
NM_002168.4
p.P158Q
c.473C>A
1 paper
NM_002168.4
p.N156S
c.467A>G
2 papers
NM_002168.4
p.P158P
c.474A>G
3 papers
NM_002168.4
p.R159C
c.475C>T
1 paper
NM_002168.4
p.R159G
c.475C>G
1 paper
NM_002168.4
p.R159S
c.475C>A
1 paper
NM_002168.4
p.K155N
c.465A>T
1 paper
NM_002168.4
p.K155N
c.465A>C
8 papers
NM_002168.4
p.R159H
c.476G>A
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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."