Varaico: Literature-Extracted Genetic Variants

Gene:IDH2
Variant:p.I153M

IDH2

2,456 papers

RefSeq Summary

Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor...

Pfam Domains

Iso_dhaa 45–441UCSCIsocitrate/isopropylmalate dehydrogenase

Gene Aliases

HGNC Name

isocitrate dehydrogenase (NADP(+)) 2

HGNC Alias Symbol

IDH-2

Papers
RefSeq ID
Protein change
DNA change
Selected Variant
1 paper
NM_002168.4
p.I153M
c.459C>G
Surrounding Variants
1 paper
NM_002168.4
p.C154R
c.460T>C
2 papers
NM_002168.4
p.I153V
c.457A>G
1 paper
NM_002168.4
p.I152S
c.455T>G
1 paper
NM_002168.4
p.K155E
c.463A>G
1 paper
NM_002168.4
p.K155Q
c.463A>C
2 papers
NM_002168.4
p.K155R
c.464A>G
1 paper
NM_002168.4
p.K155T
c.464A>C
1 paper
NM_002168.4
p.P151P
c.453C>T
1 paper
NM_002168.4
p.K155N
c.465A>T
1 paper
NM_002168.4
p.K155N
c.465A>C
1 paper
NM_002168.4
p.P151H
c.452C>A
1 paper
NM_002168.4
p.P151A
c.451C>G
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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."