Varaico: Literature-Extracted Genetic Variants

Gene:IDH2
Variant:p.N136S

IDH2

2,456 papers

RefSeq Summary

Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor...

Pfam Domains

Iso_dhaa 45–441UCSCIsocitrate/isopropylmalate dehydrogenase

Gene Aliases

HGNC Name

isocitrate dehydrogenase (NADP(+)) 2

HGNC Alias Symbol

IDH-2

Papers
RefSeq ID
Protein change
DNA change
Selected Variant
3 papers
NM_002168.4
p.N136S
c.407A>G
Surrounding Variants
1 paper
NM_002168.4
p.N136Y
c.406A>T
2 papers
NM_002168.4
p.G137R
c.409G>C
2 papers
NM_002168.4
p.G137R
c.409G>A
6 papers
NM_002168.4
p.G137E
c.410G>A
2 papers
NM_002168.4
p.P135L
c.404C>T
1 paper
NM_002168.4
p.P135H
c.404C>A
2 papers
NM_002168.4
p.T138T
c.414T>C
1 paper
NM_002168.4
p.I139F
c.415A>T
2 papers
NM_002168.4
p.I139T
c.416T>C
1 paper
NM_002168.4
p.I139N
c.416T>A
2 papers
NM_002168.4
p.K133R
c.398A>G
1 paper
NM_002168.4
p.I139M
c.417C>G
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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."