Varaico: Literature-Extracted Genetic Variants

Gene:IDH2
Variant:p.K106R

IDH2

2,456 papers

RefSeq Summary

Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor...

Pfam Domains

Iso_dhaa 45–441UCSCIsocitrate/isopropylmalate dehydrogenase

Gene Aliases

HGNC Name

isocitrate dehydrogenase (NADP(+)) 2

HGNC Alias Symbol

IDH-2

Papers
RefSeq ID
Protein change
DNA change
Selected Variant
2 papers
NM_002168.4
p.K106R
c.317A>G
Surrounding Variants
1 paper
NM_002168.4
p.K106Q
c.316A>C
1 paper
NM_002168.4
p.Q105H
c.315G>T
2 papers
NM_002168.4
p.Y107F
c.320A>T
1 paper
NM_002168.4
p.Y107*
c.321C>G
1 paper
NM_002168.4
p.Y107fs
c.319_320fs
1 paper
NM_002168.4
p.Y107*
c.321C>A
1 paper
NM_002168.4
p.T104T
c.312C>T
1 paper
NM_002168.4
p.T104Fs
c.312delinsACFs
1 paper
NM_002168.4
p.V109M
c.325G>A
1 paper
NM_002168.4
p.Q95_A103del0
c.284_307del24
1 paper
NM_002168.4
p.V109V
c.327G>A
1 paper
NM_002168.4
p.L102delFs
c.304delG
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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."