Varaico: Literature-Extracted Genetic Variants

IKBKE

234 papers

RefSeq Summary

IKBKE is a noncanonical I-kappa-B (see MIM 164008) kinase (IKK) that is essential for regulating antiviral signaling pathways. IKBKE has also been identified as a breast cancer (MIM 114480) oncogene a...

Pfam Domains

Pkinaseaa 9–301UCSCProtein kinase domain

TBK1_ULDaa 308–393UCSCTANK binding kinase 1 ubiquitin-like domain

TBK1_CCD1aa 400–646UCSCTANK-binding kinase 1 coiled-coil domain 1

Gene Aliases

HGNC Name

inhibitor of nuclear factor kappa B kinase subunit epsilon

HGNC Alias Symbols

IKKE; IKK-i; KIAA0151

Papers

RefSeq ID

Protein change

DNA change

1–12 of 300 variants

15 papers

NM_014002.4

p.P713L

c.2138C>T

7 papers

NM_014002.4

p.A371T

c.1111G>A

7 papers

NM_014002.4

p.A602V

c.1805C>T

5 papers

NM_014002.4

p.N124I

c.371A>T

5 papers

NM_014002.4

p.G660E

c.1979G>A

4 papers

NM_014002.4

p.K30R

c.89A>G

4 papers

NM_014002.4

p.R127W

c.379C>T

4 papers

NM_014002.4

p.R187Q

c.560G>A

4 papers

NM_014002.4

p.T239T

c.717G>A

4 papers

NM_014002.4

p.K401R

c.1202A>G

3 papers

NM_014002.4

p.R49L

c.146G>T

3 papers

NM_014002.4

p.S96C

c.286A>T