Varaico: Literature-Extracted Genetic Variants

IKBKE

234 papers

RefSeq Summary

IKBKE is a noncanonical I-kappa-B (see MIM 164008) kinase (IKK) that is essential for regulating antiviral signaling pathways. IKBKE has also been identified as a breast cancer (MIM 114480) oncogene a...

Pfam Domains

Pkinaseaa 9–301UCSCProtein kinase domain

TBK1_ULDaa 308–393UCSCTANK binding kinase 1 ubiquitin-like domain

TBK1_CCD1aa 400–646UCSCTANK-binding kinase 1 coiled-coil domain 1

Gene Aliases

HGNC Name

inhibitor of nuclear factor kappa B kinase subunit epsilon

HGNC Alias Symbols

IKKE; IKK-i; KIAA0151

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_014002.4

p.V58V

c.174C>T

Surrounding Variants

1 paper

NM_014002.4

p.V58G

c.173T>G

1 paper

NM_014002.4

p.R60P

c.179G>C

1 paper

NM_014002.4

p.K61R

c.182A>G

1 paper

NM_014002.4

p.L62P

c.185T>C

1 paper

NM_014002.4

p.L62R

c.185T>G

1 paper

NM_014002.4

p.R54W

c.160A>T

1 paper

NM_014002.4

p.Q52R

c.155A>G

1 paper

NM_014002.4

p.E50K

c.148G>A

2 papers

NM_014002.4

p.I67I

c.201T>C

2 papers

NM_014002.4

p.V68I

c.202G>A

3 papers

NM_014002.4

p.R49L

c.146G>T

1 paper

NM_014002.4

p.V68D

c.203T>A