Varaico: Literature-Extracted Genetic Variants

IKBKE

234 papers

RefSeq Summary

IKBKE is a noncanonical I-kappa-B (see MIM 164008) kinase (IKK) that is essential for regulating antiviral signaling pathways. IKBKE has also been identified as a breast cancer (MIM 114480) oncogene a...

Pfam Domains

Pkinaseaa 9–301UCSCProtein kinase domain

TBK1_ULDaa 308–393UCSCTANK binding kinase 1 ubiquitin-like domain

TBK1_CCD1aa 400–646UCSCTANK-binding kinase 1 coiled-coil domain 1

Gene Aliases

HGNC Name

inhibitor of nuclear factor kappa B kinase subunit epsilon

HGNC Alias Symbols

IKKE; IKK-i; KIAA0151

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_014002.4

p.F105fs

c.313_314fs

Surrounding Variants

1 paper

NM_014002.4

p.A104V

c.311C>T

1 paper

NM_014002.4

p.A104delFs

c.312delC

1 paper

NM_014002.4

p.P108S

c.322C>T

1 paper

NM_014002.4

p.S100R

c.300C>A

1 paper

NM_014002.4

p.S100R

c.300C>G

1 paper

NM_014002.4

p.S100R

c.298A>C

3 papers

NM_014002.4

p.S96C

c.286A>T

1 paper

NM_014002.4

p.S93N

c.278G>A

2 papers

NM_014002.4

p.R117C

c.349C>T

3 papers

NM_014002.4

p.R117H

c.350G>A

1 paper

NM_014002.4

p.G92W

c.274G>T

1 paper

NM_014002.4

p.V119V

c.357G>C