Varaico: Literature-Extracted Genetic Variants

IKBKE

234 papers

RefSeq Summary

IKBKE is a noncanonical I-kappa-B (see MIM 164008) kinase (IKK) that is essential for regulating antiviral signaling pathways. IKBKE has also been identified as a breast cancer (MIM 114480) oncogene a...

Pfam Domains

Pkinaseaa 9–301UCSCProtein kinase domain

TBK1_ULDaa 308–393UCSCTANK binding kinase 1 ubiquitin-like domain

TBK1_CCD1aa 400–646UCSCTANK-binding kinase 1 coiled-coil domain 1

Gene Aliases

HGNC Name

inhibitor of nuclear factor kappa B kinase subunit epsilon

HGNC Alias Symbols

IKKE; IKK-i; KIAA0151

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

2 papers

NM_014002.4

p.R134C

c.400C>T

Surrounding Variants

1 paper

NM_014002.4

p.D135N

c.403G>A

1 paper

NM_014002.4

p.V132A

c.395T>C

1 paper

NM_014002.4

p.I136V

c.406A>G

1 paper

NM_014002.4

p.I131T

c.392T>C

1 paper

NM_014002.4

p.G130S

c.388G>A

1 paper

NM_014002.4

p.N140D

c.418A>G

1 paper

NM_014002.4

p.N140S

c.419A>G

1 paper

NM_014002.4

p.R127_E128ins1

c.381_382insATC

1 paper

NM_014002.4

p.R127L

c.380G>T

1 paper

NM_014002.4

p.I141F

c.421A>T

4 papers

NM_014002.4

p.R127W

c.379C>T

2 papers

NM_014002.4

p.R143C

c.427C>T