Varaico: Literature-Extracted Genetic Variants

IKBKE

234 papers

RefSeq Summary

IKBKE is a noncanonical I-kappa-B (see MIM 164008) kinase (IKK) that is essential for regulating antiviral signaling pathways. IKBKE has also been identified as a breast cancer (MIM 114480) oncogene a...

Pfam Domains

Pkinaseaa 9–301UCSCProtein kinase domain

TBK1_ULDaa 308–393UCSCTANK binding kinase 1 ubiquitin-like domain

TBK1_CCD1aa 400–646UCSCTANK-binding kinase 1 coiled-coil domain 1

Gene Aliases

HGNC Name

inhibitor of nuclear factor kappa B kinase subunit epsilon

HGNC Alias Symbols

IKKE; IKK-i; KIAA0151

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_014002.4

p.A243D

c.728C>A

Surrounding Variants

4 papers

NM_014002.4

p.T239T

c.717G>A

1 paper

NM_014002.4

p.A247V

c.740C>T

1 paper

NM_014002.4

p.R236Q

c.707G>A

1 paper

NM_014002.4

p.R236W

c.706C>T

1 paper

NM_014002.4

p.Q250H

c.750G>C

1 paper

NM_014002.4

p.Q250H

c.750G>T

1 paper

NM_014002.4

p.R251R

c.753G>A

3 papers

NM_014002.4

p.R252W

c.754C>T

1 paper

NM_014002.4

p.N254Y

c.760A>T

1 paper

NM_014002.4

p.G255W

c.763G>T

1 paper

NM_014002.4

p.E258G

c.773A>G

1 paper

NM_014002.4

p.T262A

c.784A>G