Varaico: Literature-Extracted Genetic Variants

IKBKE

234 papers

RefSeq Summary

IKBKE is a noncanonical I-kappa-B (see MIM 164008) kinase (IKK) that is essential for regulating antiviral signaling pathways. IKBKE has also been identified as a breast cancer (MIM 114480) oncogene a...

Pfam Domains

Pkinaseaa 9–301UCSCProtein kinase domain

TBK1_ULDaa 308–393UCSCTANK binding kinase 1 ubiquitin-like domain

TBK1_CCD1aa 400–646UCSCTANK-binding kinase 1 coiled-coil domain 1

Gene Aliases

HGNC Name

inhibitor of nuclear factor kappa B kinase subunit epsilon

HGNC Alias Symbols

IKKE; IKK-i; KIAA0151

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_014002.4

p.L358R

c.1073T>G

Surrounding Variants

1 paper

NM_014002.4

p.G356D

c.1067G>A

1 paper

NM_014002.4

p.G356V

c.1067G>T

1 paper

NM_014002.4

p.E355A

c.1064A>C

1 paper

NM_014002.4

p.E362K

c.1084G>A

2 papers

NM_014002.4

p.V365I

c.1093G>A

1 paper

NM_014002.4

p.E351K

c.1051G>A

2 papers

NM_014002.4

p.S366A

c.1096T>G

1 paper

NM_014002.4

p.R348Q

c.1043G>A

1 paper

NM_014002.4

p.I370M

c.1110C>G

1 paper

NM_014002.4

p.A346insFs

c.1037dupC

1 paper

NM_014002.4

p.A346fs

c.1036_1037fs

7 papers

NM_014002.4

p.A371T

c.1111G>A