Varaico: Literature-Extracted Genetic Variants

IKBKE

234 papers

RefSeq Summary

IKBKE is a noncanonical I-kappa-B (see MIM 164008) kinase (IKK) that is essential for regulating antiviral signaling pathways. IKBKE has also been identified as a breast cancer (MIM 114480) oncogene a...

Pfam Domains

Pkinaseaa 9–301UCSCProtein kinase domain

TBK1_ULDaa 308–393UCSCTANK binding kinase 1 ubiquitin-like domain

TBK1_CCD1aa 400–646UCSCTANK-binding kinase 1 coiled-coil domain 1

Gene Aliases

HGNC Name

inhibitor of nuclear factor kappa B kinase subunit epsilon

HGNC Alias Symbols

IKKE; IKK-i; KIAA0151

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_014002.4

p.P395S

c.1183C>T

Surrounding Variants

1 paper

NM_014002.4

p.F392L

c.1176C>A

1 paper

NM_014002.4

p.F392L

c.1176C>G

1 paper

NM_014002.4

p.F392L

c.1174T>C

2 papers

NM_014002.4

p.A391V

c.1172C>T

1 paper

NM_014002.4

p.G389E

c.1166G>A

1 paper

NM_014002.4

p.P395Splc

c.1183+24A>G

1 paper

NM_014002.4

p.L381_F382insATC

c.1141_1145ins9

1 paper

NM_014002.4

p.L379L

c.1137G>A

1 paper

NM_014002.4

p.L379fs

c.1135_1136fs

1 paper

NM_014002.4

p.P395Splc

c.1183+48T>C

2 papers

NM_014002.4

p.P378P

c.1134C>G

1 paper

NM_014002.4

p.S377delFs

c.1131delC