Varaico: Literature-Extracted Genetic Variants

IKBKE

234 papers

RefSeq Summary

IKBKE is a noncanonical I-kappa-B (see MIM 164008) kinase (IKK) that is essential for regulating antiviral signaling pathways. IKBKE has also been identified as a breast cancer (MIM 114480) oncogene a...

Pfam Domains

Pkinaseaa 9–301UCSCProtein kinase domain

TBK1_ULDaa 308–393UCSCTANK binding kinase 1 ubiquitin-like domain

TBK1_CCD1aa 400–646UCSCTANK-binding kinase 1 coiled-coil domain 1

Gene Aliases

HGNC Name

inhibitor of nuclear factor kappa B kinase subunit epsilon

HGNC Alias Symbols

IKKE; IKK-i; KIAA0151

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_014002.4

p.R441L

c.1322G>T

Surrounding Variants

1 paper

NM_014002.4

p.R441Q

c.1322G>A

1 paper

NM_014002.4

p.R441W

c.1321C>T

1 paper

NM_014002.4

p.G442W

c.1324G>T

1 paper

NM_014002.4

p.W445*

c.1334G>A

1 paper

NM_014002.4

p.W445*

c.1335G>A

1 paper

NM_014002.4

p.V446fs

c.1336_1337fs

1 paper

NM_014002.4

p.G435R

c.1303G>A

1 paper

NM_014002.4

p.G435R

c.1303G>C

1 paper

NM_014002.4

p.R430R

c.1290G>C

1 paper

NM_014002.4

p.R427Q

c.1280G>A

2 papers

NM_014002.4

p.A421T

c.1261G>A

3 papers

NM_014002.4

p.V418M

c.1252G>A