Varaico: Literature-Extracted Genetic Variants

IKBKE

234 papers

RefSeq Summary

IKBKE is a noncanonical I-kappa-B (see MIM 164008) kinase (IKK) that is essential for regulating antiviral signaling pathways. IKBKE has also been identified as a breast cancer (MIM 114480) oncogene a...

Pfam Domains

Pkinaseaa 9–301UCSCProtein kinase domain

TBK1_ULDaa 308–393UCSCTANK binding kinase 1 ubiquitin-like domain

TBK1_CCD1aa 400–646UCSCTANK-binding kinase 1 coiled-coil domain 1

Gene Aliases

HGNC Name

inhibitor of nuclear factor kappa B kinase subunit epsilon

HGNC Alias Symbols

IKKE; IKK-i; KIAA0151

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_014002.4

p.K644_L645Splc

c.1932+2T>G

Surrounding Variants

1 paper

NM_014002.4

p.V638L

c.1912G>C

1 paper

NM_014002.4

p.Q636Q

c.1908G>A

1 paper

NM_014002.4

p.N632D

c.1894A>G

1 paper

NM_014002.4

p.A629S

c.1885G>T

1 paper

NM_014002.4

p.C626Y

c.1877G>A

1 paper

NM_014002.4

p.R622H

c.1865G>A

1 paper

NM_014002.4

p.L621M

c.1861C>A

1 paper

NM_014002.4

p.L621V

c.1861C>G

1 paper

NM_014002.4

p.L621L

c.1861C>T

1 paper

NM_014002.4

p.R618S

c.1854G>T

1 paper

NM_014002.4

p.L645L

c.1935C>T

5 papers

NM_014002.4

p.G660E

c.1979G>A