Varaico: Literature-Extracted Genetic Variants

Gene:IL6R
Variant:p.F187Y

IL6R

691 papers

RefSeq Summary

This gene encodes a subunit of the interleukin 6 (IL6) receptor complex. Interleukin 6 is a potent pleiotropic cytokine that regulates cell growth and differentiation and plays an important role in th...

Pfam Domains

igaa 34–99UCSCImmunoglobulin domain
IL6Ra-bindaa 118–213UCSCInterleukin-6 receptor alpha chain, binding

Gene Aliases

HGNC Name

interleukin 6 receptor

HGNC Alias Symbols

CD126; IL-6R; IL-1Ra; IL6RA; gp80

Papers
RefSeq ID
Protein change
DNA change
Selected Variant
1 paper
NM_000565.4
p.F187Y
c.560T>A
Surrounding Variants
1 paper
NM_000565.4
p.S186P
c.556T>C
2 papers
NM_000565.4
p.I189V
c.565A>G
1 paper
NM_000565.4
p.I189M
c.567A>G
1 paper
NM_000565.4
p.V190G
c.569T>G
1 paper
NM_000565.4
p.D184H
c.550G>C
11 papers
NM_000565.4
p.S191C
c.572C>G
1 paper
NM_000565.4
p.G183fs
c.547_548fs
1 paper
NM_000565.4
p.M192V
c.574A>G
1 paper
NM_000565.4
p.G183delFs
c.548delG
3 papers
NM_000565.4
p.V194I
c.580G>A
1 paper
NM_000565.4
p.A195T
c.583G>A
1 paper
NM_000565.4
p.C176Y
c.527G>A
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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."