Varaico: Literature-Extracted Genetic Variants

Gene:IL6R
Variant:p.P219H

IL6R

691 papers

RefSeq Summary

This gene encodes a subunit of the interleukin 6 (IL6) receptor complex. Interleukin 6 is a potent pleiotropic cytokine that regulates cell growth and differentiation and plays an important role in th...

Pfam Domains

igaa 34–99UCSCImmunoglobulin domain
IL6Ra-bindaa 118–213UCSCInterleukin-6 receptor alpha chain, binding

Gene Aliases

HGNC Name

interleukin 6 receptor

HGNC Alias Symbols

CD126; IL-6R; IL-1Ra; IL6RA; gp80

Papers
RefSeq ID
Protein change
DNA change
Selected Variant
1 paper
NM_000565.4
p.P219H
c.656C>A
Surrounding Variants
1 paper
NM_000565.4
p.A220V
c.659C>T
1 paper
NM_000565.4
p.P218T
c.652C>A
1 paper
NM_000565.4
p.P218A
c.652C>G
1 paper
NM_000565.4
p.N221T
c.662A>C
1 paper
NM_000565.4
p.D217V
c.650A>T
1 paper
NM_000565.4
p.P216H
c.647C>A
1 paper
NM_000565.4
p.P216del1
c.646_647delCCT
2 papers
NM_000565.4
p.A226V
c.677C>T
1 paper
NM_000565.4
p.A228D
c.683C>A
1 paper
NM_000565.4
p.N230D
c.688A>G
1 paper
NM_000565.4
p.N230fs
c.688_689fs
1 paper
NM_000565.4
p.R232S
c.694C>A
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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."