Varaico: Literature-Extracted Genetic Variants

Gene:IL6R
Variant:p.E254D

IL6R

691 papers

RefSeq Summary

This gene encodes a subunit of the interleukin 6 (IL6) receptor complex. Interleukin 6 is a potent pleiotropic cytokine that regulates cell growth and differentiation and plays an important role in th...

Pfam Domains

igaa 34–99UCSCImmunoglobulin domain
IL6Ra-bindaa 118–213UCSCInterleukin-6 receptor alpha chain, binding

Gene Aliases

HGNC Name

interleukin 6 receptor

HGNC Alias Symbols

CD126; IL-6R; IL-1Ra; IL6RA; gp80

Papers
RefSeq ID
Protein change
DNA change
Selected Variant
1 paper
NM_000565.4
p.E254D
c.762G>C
Surrounding Variants
1 paper
NM_000565.4
p.E254A
c.761A>C
1 paper
NM_000565.4
p.E254V
c.761A>T
1 paper
NM_000565.4
p.L255H
c.764T>A
1 paper
NM_000565.4
p.R256S
c.768A>C
1 paper
NM_000565.4
p.R256R
c.768A>G
1 paper
NM_000565.4
p.R256S
c.768A>T
1 paper
NM_000565.4
p.R252Q
c.755G>A
1 paper
NM_000565.4
p.Y257D
c.769T>G
1 paper
NM_000565.4
p.R258Q
c.773G>A
1 paper
NM_000565.4
p.R250S
c.750A>C
1 paper
NM_000565.4
p.R250S
c.750A>T
1 paper
NM_000565.4
p.R250K
c.749G>A
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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."