Varaico: Literature-Extracted Genetic Variants

INTS4

93 papers

RefSeq Summary

INTS4 is a subunit of the Integrator complex, which associates with the C-terminal domain of RNA polymerase II large subunit (POLR2A; MIM 180660) and mediates 3-prime end processing of small nuclear R...

Pfam Domains

PDS5aa 76–345UCSCSister chromatid cohesion protein PDS5 protein

HEAT_2aa 378–472UCSCHEAT repeats

INTS4_8HBDaa 611–815UCSCINTS4 8 helical bundle domain

INTS4_Caa 823–961UCSCIntegrator subunit 4 family C-terminal Ig-like domain

Gene Aliases

HGNC Name

integrator complex subunit 4

HGNC Alias Symbols

INT4; MGC16733; MST093

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_033547.4

p.S949S

c.2847C>T

Surrounding Variants

1 paper

NM_033547.4

p.K953E

c.2857A>G

1 paper

NM_033547.4

p.G944D

c.2831G>A

1 paper

NM_033547.4

p.P960T

c.2878C>A

1 paper

NM_033547.4

p.R963C

c.2887C>T

1 paper

NM_033547.4

p.G932fs

c.2794_2795fs

1 paper

NM_033547.4

p.G931insFs

c.2792dupG

2 papers

NM_033547.4

p.Y897S

c.2690A>C

1 paper

NM_033547.4

p.R891W

c.2671C>T

1 paper

NM_033547.4

p.P885A

c.2653C>G