Varaico: Literature-Extracted Genetic Variants

Gene:IRAK1
Variant:p.P621P

IRAK1

294 papers

RefSeq Summary

This gene encodes the interleukin-1 receptor-associated kinase 1, one of two putative serine/threonine kinases that become associated with the interleukin-1 receptor (IL1R) upon stimulation. This gene...

Pfam Domains

Deathaa 27–103UCSCDeath domain
Pkinaseaa 212–517UCSCProtein kinase domain

Gene Aliases

HGNC Name

interleukin 1 receptor associated kinase 1

HGNC Alias Symbol

pelle

Papers
RefSeq ID
Protein change
DNA change
Selected Variant
1 paper
NM_001569.4
p.P621P
c.1863T>C
Surrounding Variants
1 paper
NM_001569.4
p.C620_P621del2
c.1858_1862del6
1 paper
NM_001569.4
p.G619S
c.1855G>A
1 paper
NM_001569.4
p.T625M
c.1874C>T
1 paper
NM_001569.4
p.G632G
c.1896G>A
1 paper
NM_001569.4
p.R638W
c.1912C>T
1 paper
NM_001569.4
p.L595F
c.1783C>T
1 paper
NM_001569.4
p.E590*
c.1768G>T
1 paper
NM_001569.4
p.S588C
c.1762A>T
2 papers
NM_001569.4
p.E587A
c.1760A>C
1 paper
NM_001569.4
p.E587K
c.1759G>A
1 paper
NM_001569.4
p.V586M
c.1756G>A
1 paper
NM_001569.4
p.P585P
c.1755C>A
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