Varaico: Literature-Extracted Genetic Variants

Gene:IRAK3
Variant:p.L109F

IRAK3

102 papers

RefSeq Summary

This gene encodes a member of the interleukin-1 receptor-associated kinase protein family. Members of this family are essential components of the Toll/IL-R immune signal transduction pathways. This pr...

Pfam Domains

Deathaa 25–106UCSCDeath domain
Pkinaseaa 165–443UCSCProtein kinase domain

Gene Aliases

HGNC Name

interleukin 1 receptor associated kinase 3

HGNC Alias Symbol

IRAK-M

Papers
RefSeq ID
Protein change
DNA change
Selected Variant
2 papers
NM_007199.3
p.L109F
c.327G>C
Surrounding Variants
2 papers
NM_007199.3
p.L109F
c.327G>T
2 papers
NM_007199.3
p.P111A
c.331C>G
1 paper
NM_007199.3
p.S115R
c.345T>A
1 paper
NM_007199.3
p.F121L
c.361T>C
1 paper
NM_007199.3
p.F121L
c.363T>A
1 paper
NM_007199.3
p.F121L
c.363T>G
1 paper
NM_007199.3
p.L125V
c.373T>G
2 papers
NM_007199.3
p.K127_E128Splc
c.381+1G>T
1 paper
NM_007199.3
p.K127_E128Splc
c.381+99C>T
1 paper
NM_007199.3
p.N131Y
c.391A>T
3 papers
NM_007199.3
p.V134M
c.400G>A
1 paper
NM_007199.3
p.D135N
c.403G>A
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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."