Varaico: Literature-Extracted Genetic Variants

Gene:IRS1
Variant:p.I1019T

IRS1

686 papers

RefSeq Summary

This gene encodes a protein which is phosphorylated by insulin receptor tyrosine kinase. Mutations in this gene are associated with type II diabetes and susceptibility to insulin resistance. [provided...

Pfam Domains

PHaa 8–115UCSCPH domain
IRSaa 166–261UCSCPTB domain (IRS-1 type)

Gene Aliases

HGNC Name

insulin receptor substrate 1

HGNC Alias Symbol

HIRS-1

Papers
RefSeq ID
Protein change
DNA change
Selected Variant
3 papers
NM_005544.3
p.I1019T
c.3056T>C
Surrounding Variants
1 paper
NM_005544.3
p.A1021T
c.3061G>A
2 papers
NM_005544.3
p.D1014G
c.3041A>G
1 paper
NM_005544.3
p.M1031I
c.3093G>A
1 paper
NM_005544.3
p.D1003Y
c.3007G>T
1 paper
NM_005544.3
p.D1003H
c.3007G>C
2 papers
NM_005544.3
p.S1036A
c.3106T>G
1 paper
NM_005544.3
p.S1036L
c.3107C>T
1 paper
NM_005544.3
p.A1040G
c.3119C>G
1 paper
NM_005544.3
p.S1041A
c.3121T>G
1 paper
NM_005544.3
p.P997S
c.2989C>T
5 papers
NM_005544.3
p.S1043Y
c.3128C>A
1 paper
NM_005544.3
p.M990V
c.2968A>G
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