Varaico: Literature-Extracted Genetic Variants

Gene:IRS1
Variant:p.G963insFs

IRS1

686 papers

RefSeq Summary

This gene encodes a protein which is phosphorylated by insulin receptor tyrosine kinase. Mutations in this gene are associated with type II diabetes and susceptibility to insulin resistance. [provided...

Pfam Domains

PHaa 8–115UCSCPH domain
IRSaa 166–261UCSCPTB domain (IRS-1 type)

Gene Aliases

HGNC Name

insulin receptor substrate 1

HGNC Alias Symbol

HIRS-1

Papers
RefSeq ID
Protein change
DNA change
Selected Variant
1 paper
NM_005544.3
p.G963insFs
c.2887_2888insTC
Surrounding Variants
1 paper
NM_005544.3
p.M962delFs
c.2885_2886delCA
1 paper
NM_005544.3
p.V960A
c.2879T>C
1 paper
NM_005544.3
p.P970A
c.2908C>G
1 paper
NM_005544.3
p.P970T
c.2908C>A
38 papers
NM_005544.3
p.G971R
c.2911G>C
40 papers
NM_005544.3
p.G971R
c.2911G>A
1 paper
NM_005544.3
p.G971A
c.2912G>C
1 paper
NM_005544.3
p.R951G
c.2851A>G
1 paper
NM_005544.3
p.K943Q
c.2827A>C
1 paper
NM_005544.3
p.G937G
c.2811C>T
1 paper
NM_005544.3
p.M990V
c.2968A>G
1 paper
NM_005544.3
p.P997S
c.2989C>T
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