Varaico: Literature-Extracted Genetic Variants

Gene:IRS2
Variant:p.G1191_G1195delFs

IRS2

613 papers

RefSeq Summary

This gene encodes the insulin receptor substrate 2, a cytoplasmic signaling molecule that mediates effects of insulin, insulin-like growth factor 1, and other cytokines by acting as a molecular adapto...

Pfam Domains

PHaa 31–144UCSCPH domain
IRSaa 200–295UCSCPTB domain (IRS-1 type)

Gene Aliases

HGNC Name

insulin receptor substrate 2

Papers
RefSeq ID
Protein change
DNA change
Selected Variant
1 paper
NM_003749.3
p.G1191_G1195delFs
c.3573_3583del11
Surrounding Variants
1 paper
NM_003749.3
p.G1195G
c.3585A>G
1 paper
NM_003749.3
p.G1191fs
c.3571_3572fs
1 paper
NM_003749.3
p.E1199K
c.3595G>A
1 paper
NM_003749.3
p.P1200L
c.3599C>T
1 paper
NM_003749.3
p.V1190M
c.3568G>A
1 paper
NM_003749.3
p.G1189D
c.3566G>A
1 paper
NM_003749.3
p.P1201L
c.3602C>T
1 paper
NM_003749.3
p.G1189S
c.3565G>A
1 paper
NM_003749.3
p.T1202S
c.3604A>T
1 paper
NM_003749.3
p.T1202S
c.3605C>G
1 paper
NM_003749.3
p.R1205L
c.3614G>T
1 paper
NM_003749.3
p.S1185N
c.3554G>A
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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."