Varaico: Literature-Extracted Genetic Variants

Gene:IRS2
Variant:p.P1036del1

IRS2

613 papers

RefSeq Summary

This gene encodes the insulin receptor substrate 2, a cytoplasmic signaling molecule that mediates effects of insulin, insulin-like growth factor 1, and other cytokines by acting as a molecular adapto...

Pfam Domains

PHaa 31–144UCSCPH domain
IRSaa 200–295UCSCPTB domain (IRS-1 type)

Gene Aliases

HGNC Name

insulin receptor substrate 2

Papers
RefSeq ID
Protein change
DNA change
Selected Variant
1 paper
NM_003749.3
p.P1036del1
c.3106_3107delCGG
Surrounding Variants
1 paper
NM_003749.3
p.P1033_P1036del0
c.3099_3107del9
1 paper
NM_003749.3
p.P1033_P1035del0
c.3099_3104del6
1 paper
NM_003749.3
p.P1038L
c.3113C>T
1 paper
NM_003749.3
p.G1039R
c.3115G>C
1 paper
NM_003749.3
p.G1039R
c.3115G>A
4 papers
NM_003749.3
p.P1033del1
c.3097_3098delTGG
1 paper
NM_003749.3
p.P1034L
c.3101C>T
1 paper
NM_003749.3
p.E1040Q
c.3118G>C
1 paper
NM_003749.3
p.P1031_P1033delins
c.3093_3099delinsACCGCCG
2 papers
NM_003749.3
p.P1033S
c.3097C>T
1 paper
NM_003749.3
p.L1041L
c.3123G>T
1 paper
NM_003749.3
p.P1032S
c.3094C>T
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