Varaico: Literature-Extracted Genetic Variants

Gene:IRS2
Variant:p.F880L

IRS2

613 papers

RefSeq Summary

This gene encodes the insulin receptor substrate 2, a cytoplasmic signaling molecule that mediates effects of insulin, insulin-like growth factor 1, and other cytokines by acting as a molecular adapto...

Pfam Domains

PHaa 31–144UCSCPH domain
IRSaa 200–295UCSCPTB domain (IRS-1 type)

Gene Aliases

HGNC Name

insulin receptor substrate 2

Papers
RefSeq ID
Protein change
DNA change
Selected Variant
2 papers
NM_003749.3
p.F880L
c.2640C>G
Surrounding Variants
2 papers
NM_003749.3
p.F880L
c.2640C>A
2 papers
NM_003749.3
p.F880L
c.2638T>C
2 papers
NM_003749.3
p.G879D
c.2636G>A
7 papers
NM_003749.3
p.G882A
c.2645G>C
14 papers
NM_003749.3
p.G879S
c.2635G>A
1 paper
NM_003749.3
p.E878Q
c.2632G>C
1 paper
NM_003749.3
p.A887V
c.2660C>T
1 paper
NM_003749.3
p.P890A
c.2668C>G
1 paper
NM_003749.3
p.R871W
c.2611C>T
2 papers
NM_003749.3
p.V870M
c.2608G>A
1 paper
NM_003749.3
p.S868S
c.2604G>A
1 paper
NM_003749.3
p.E896D
c.2688G>T
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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."