Varaico: Literature-Extracted Genetic Variants

Gene:IRS2
Variant:p.H863Y

IRS2

613 papers

RefSeq Summary

This gene encodes the insulin receptor substrate 2, a cytoplasmic signaling molecule that mediates effects of insulin, insulin-like growth factor 1, and other cytokines by acting as a molecular adapto...

Pfam Domains

PHaa 31–144UCSCPH domain
IRSaa 200–295UCSCPTB domain (IRS-1 type)

Gene Aliases

HGNC Name

insulin receptor substrate 2

Papers
RefSeq ID
Protein change
DNA change
Selected Variant
1 paper
NM_003749.3
p.H863Y
c.2587C>T
Surrounding Variants
1 paper
NM_003749.3
p.P862H
c.2585C>A
1 paper
NM_003749.3
p.Q860K
c.2578C>A
1 paper
NM_003749.3
p.T859M
c.2576C>T
1 paper
NM_003749.3
p.S868S
c.2604G>A
1 paper
NM_003749.3
p.G857D
c.2570G>A
2 papers
NM_003749.3
p.V870M
c.2608G>A
1 paper
NM_003749.3
p.A856T
c.2566G>A
1 paper
NM_003749.3
p.G855R
c.2563G>C
1 paper
NM_003749.3
p.G855R
c.2563G>A
1 paper
NM_003749.3
p.R871W
c.2611C>T
1 paper
NM_003749.3
p.F854V
c.2560T>G
1 paper
NM_003749.3
p.A850T
c.2548G>A
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