Varaico: Literature-Extracted Genetic Variants

Gene:IRS2
Variant:p.F783L

IRS2

613 papers

RefSeq Summary

This gene encodes the insulin receptor substrate 2, a cytoplasmic signaling molecule that mediates effects of insulin, insulin-like growth factor 1, and other cytokines by acting as a molecular adapto...

Pfam Domains

PHaa 31–144UCSCPH domain
IRSaa 200–295UCSCPTB domain (IRS-1 type)

Gene Aliases

HGNC Name

insulin receptor substrate 2

Papers
RefSeq ID
Protein change
DNA change
Selected Variant
1 paper
NM_003749.3
p.F783L
c.2349C>G
Surrounding Variants
1 paper
NM_003749.3
p.F783L
c.2349C>A
1 paper
NM_003749.3
p.F783L
c.2347T>C
2 papers
NM_003749.3
p.D782N
c.2344G>A
1 paper
NM_003749.3
p.F784_S785del1
c.2351_2353delAGA
1 paper
NM_003749.3
p.A787T
c.2359G>A
1 paper
NM_003749.3
p.H789Y
c.2365C>T
1 paper
NM_003749.3
p.H789L
c.2366A>T
1 paper
NM_003749.3
p.G791D
c.2372G>A
1 paper
NM_003749.3
p.V775insFs
c.2324_2325ins8
1 paper
NM_003749.3
p.V775I
c.2323G>A
1 paper
NM_003749.3
p.P794S
c.2380C>T
1 paper
NM_003749.3
p.P794R
c.2381C>G
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