Varaico: Literature-Extracted Genetic Variants

Gene:IRS2
Variant:p.R744C

IRS2

613 papers

RefSeq Summary

This gene encodes the insulin receptor substrate 2, a cytoplasmic signaling molecule that mediates effects of insulin, insulin-like growth factor 1, and other cytokines by acting as a molecular adapto...

Pfam Domains

PHaa 31–144UCSCPH domain
IRSaa 200–295UCSCPTB domain (IRS-1 type)

Gene Aliases

HGNC Name

insulin receptor substrate 2

Papers
RefSeq ID
Protein change
DNA change
Selected Variant
2 papers
NM_003749.3
p.R744C
c.2230C>T
Surrounding Variants
1 paper
NM_003749.3
p.S740S
c.2220T>C
1 paper
NM_003749.3
p.C747C
c.2241C>T
2 papers
NM_003749.3
p.S749F
c.2246C>T
1 paper
NM_003749.3
p.K750*
c.2248A>T
1 paper
NM_003749.3
p.S736F
c.2207C>T
1 paper
NM_003749.3
p.S736A
c.2206T>G
1 paper
NM_003749.3
p.E754D
c.2262G>T
1 paper
NM_003749.3
p.E754D
c.2262G>C
1 paper
NM_003749.3
p.A756V
c.2267C>T
2 papers
NM_003749.3
p.S731A
c.2191T>G
1 paper
NM_003749.3
p.S730R
c.2190C>G
1 paper
NM_003749.3
p.S730R
c.2190C>A
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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."