Varaico: Literature-Extracted Genetic Variants

Gene:IRS2
Variant:p.S669R

IRS2

613 papers

RefSeq Summary

This gene encodes the insulin receptor substrate 2, a cytoplasmic signaling molecule that mediates effects of insulin, insulin-like growth factor 1, and other cytokines by acting as a molecular adapto...

Pfam Domains

PHaa 31–144UCSCPH domain
IRSaa 200–295UCSCPTB domain (IRS-1 type)

Gene Aliases

HGNC Name

insulin receptor substrate 2

Papers
RefSeq ID
Protein change
DNA change
Selected Variant
1 paper
NM_003749.3
p.S669R
c.2005A>C
Surrounding Variants
1 paper
NM_003749.3
p.G668A
c.2003G>C
1 paper
NM_003749.3
p.S669R
c.2007C>G
1 paper
NM_003749.3
p.S669R
c.2007C>A
1 paper
NM_003749.3
p.S667R
c.2001C>A
1 paper
NM_003749.3
p.S672N
c.2015G>A
1 paper
NM_003749.3
p.S672S
c.2016C>T
1 paper
NM_003749.3
p.G664C
c.1990G>T
1 paper
NM_003749.3
p.D674H
c.2020G>C
2 papers
NM_003749.3
p.A663V
c.1988C>T
1 paper
NM_003749.3
p.A663T
c.1987G>A
1 paper
NM_003749.3
p.A661T
c.1981G>A
1 paper
NM_003749.3
p.A660V
c.1979C>T
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