Varaico: Literature-Extracted Genetic Variants

Gene:IRS2
Variant:p.L647V

IRS2

613 papers

RefSeq Summary

This gene encodes the insulin receptor substrate 2, a cytoplasmic signaling molecule that mediates effects of insulin, insulin-like growth factor 1, and other cytokines by acting as a molecular adapto...

Pfam Domains

PHaa 31–144UCSCPH domain
IRSaa 200–295UCSCPTB domain (IRS-1 type)

Gene Aliases

HGNC Name

insulin receptor substrate 2

Papers
RefSeq ID
Protein change
DNA change
Selected Variant
8 papers
NM_003749.3
p.L647V
c.1939C>G
Surrounding Variants
1 paper
NM_003749.3
p.G648R
c.1942G>C
1 paper
NM_003749.3
p.G648R
c.1942G>A
1 paper
NM_003749.3
p.M654I
c.1962G>T
1 paper
NM_003749.3
p.P655S
c.1963C>T
1 paper
NM_003749.3
p.P655L
c.1964C>T
1 paper
NM_003749.3
p.I637F
c.1909A>T
1 paper
NM_003749.3
p.E636D
c.1908G>T
1 paper
NM_003749.3
p.E636D
c.1908G>C
1 paper
NM_003749.3
p.I635M
c.1905C>G
1 paper
NM_003749.3
p.G659S
c.1975G>A
1 paper
NM_003749.3
p.A660V
c.1979C>T
1 paper
NM_003749.3
p.A661T
c.1981G>A
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