Varaico: Literature-Extracted Genetic Variants

Gene:IRS2
Variant:p.Y576_S577del1

IRS2

613 papers

RefSeq Summary

This gene encodes the insulin receptor substrate 2, a cytoplasmic signaling molecule that mediates effects of insulin, insulin-like growth factor 1, and other cytokines by acting as a molecular adapto...

Pfam Domains

PHaa 31–144UCSCPH domain
IRSaa 200–295UCSCPTB domain (IRS-1 type)

Gene Aliases

HGNC Name

insulin receptor substrate 2

Papers
RefSeq ID
Protein change
DNA change
Selected Variant
1 paper
NM_003749.3
p.Y576_S577del1
c.1728_1730delGAG
Surrounding Variants
1 paper
NM_003749.3
p.S577P
c.1729T>C
1 paper
NM_003749.3
p.D568_Y576del0
c.1704_1727del24
1 paper
NM_003749.3
p.R583Q
c.1748G>A
1 paper
NM_003749.3
p.R558_R572del0
c.1673_1714del42
1 paper
NM_003749.3
p.R572C
c.1714C>T
1 paper
NM_003749.3
p.R585Q
c.1754G>A
1 paper
NM_003749.3
p.P586L
c.1757C>T
1 paper
NM_003749.3
p.D568N
c.1702G>A
1 paper
NM_003749.3
p.V559_Q565del0
c.1675_1695del21
1 paper
NM_003749.3
p.Q565P
c.1694A>C
1 paper
NM_003749.3
p.A564V
c.1691C>T
1 paper
NM_003749.3
p.R554_A563del0
c.1662_1688del27
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