Varaico: Literature-Extracted Genetic Variants

Gene:IRS2
Variant:p.V559A

IRS2

613 papers

RefSeq Summary

This gene encodes the insulin receptor substrate 2, a cytoplasmic signaling molecule that mediates effects of insulin, insulin-like growth factor 1, and other cytokines by acting as a molecular adapto...

Pfam Domains

PHaa 31–144UCSCPH domain
IRSaa 200–295UCSCPTB domain (IRS-1 type)

Gene Aliases

HGNC Name

insulin receptor substrate 2

Papers
RefSeq ID
Protein change
DNA change
Selected Variant
1 paper
NM_003749.3
p.V559A
c.1676T>C
Surrounding Variants
1 paper
NM_003749.3
p.V559G
c.1676T>G
1 paper
NM_003749.3
p.V559D
c.1676T>A
1 paper
NM_003749.3
p.V559del1
c.1675_1676delGAC
1 paper
NM_003749.3
p.Y556_R557del1
c.1668_1670delCGG
1 paper
NM_003749.3
p.G553_R557del0
c.1659_1670del12
4 papers
NM_003749.3
p.R558P
c.1673G>C
1 paper
NM_003749.3
p.Y556_R558del0
c.1667_1672del6
1 paper
NM_003749.3
p.S550_R558delFs
c.1648_1672del25
1 paper
NM_003749.3
p.Y556_S560del0
c.1668_1679del12
1 paper
NM_003749.3
p.Y556_G561del0
c.1667_1681del15
1 paper
NM_003749.3
p.H551_R557del0
c.1652_1669del18
1 paper
NM_003749.3
p.R554_G561del0
c.1660_1683del24
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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."