Varaico: Literature-Extracted Genetic Variants

Gene:IRS2
Variant:p.S506G

IRS2

613 papers

RefSeq Summary

This gene encodes the insulin receptor substrate 2, a cytoplasmic signaling molecule that mediates effects of insulin, insulin-like growth factor 1, and other cytokines by acting as a molecular adapto...

Pfam Domains

PHaa 31–144UCSCPH domain
IRSaa 200–295UCSCPTB domain (IRS-1 type)

Gene Aliases

HGNC Name

insulin receptor substrate 2

Papers
RefSeq ID
Protein change
DNA change
Selected Variant
1 paper
NM_003749.3
p.S506G
c.1516A>G
Surrounding Variants
1 paper
NM_003749.3
p.G508S
c.1522G>A
1 paper
NM_003749.3
p.D501ins2
c.1502_1503ins6
1 paper
NM_003749.3
p.D501ins2
c.1502_1503ins6
2 papers
NM_003749.3
p.A512P
c.1534G>C
6 papers
NM_003749.3
p.A512T
c.1534G>A
1 paper
NM_003749.3
p.L500V
c.1498C>G
1 paper
NM_003749.3
p.A512A
c.1536C>T
1 paper
NM_003749.3
p.M498L
c.1492A>T
1 paper
NM_003749.3
p.M498L
c.1492A>C
1 paper
NM_003749.3
p.H516fs
c.1546_1547fs
2 papers
NM_003749.3
p.P492S
c.1474C>T
1 paper
NM_003749.3
p.S491Y
c.1472C>A
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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."