Varaico: Literature-Extracted Genetic Variants

Gene:IRS2
Variant:p.P477P

IRS2

613 papers

RefSeq Summary

This gene encodes the insulin receptor substrate 2, a cytoplasmic signaling molecule that mediates effects of insulin, insulin-like growth factor 1, and other cytokines by acting as a molecular adapto...

Pfam Domains

PHaa 31–144UCSCPH domain
IRSaa 200–295UCSCPTB domain (IRS-1 type)

Gene Aliases

HGNC Name

insulin receptor substrate 2

Papers
RefSeq ID
Protein change
DNA change
Selected Variant
2 papers
NM_003749.3
p.P477P
c.1431C>T
Surrounding Variants
1 paper
NM_003749.3
p.G476A
c.1427G>C
1 paper
NM_003749.3
p.R480W
c.1438C>T
1 paper
NM_003749.3
p.H475Y
c.1423C>T
1 paper
NM_003749.3
p.P472S
c.1414C>T
1 paper
NM_003749.3
p.G484A
c.1451G>C
1 paper
NM_003749.3
p.L469V
c.1405C>G
2 papers
NM_003749.3
p.P468R
c.1403C>G
1 paper
NM_003749.3
p.G464insFs
c.1392dupC
2 papers
NM_003749.3
p.G490S
c.1468G>A
1 paper
NM_003749.3
p.S491Y
c.1472C>A
2 papers
NM_003749.3
p.P492S
c.1474C>T
1 paper
NM_003749.3
p.P460L
c.1379C>T
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