Varaico: Literature-Extracted Genetic Variants

Gene:IRS2
Variant:p.S449W

IRS2

613 papers

RefSeq Summary

This gene encodes the insulin receptor substrate 2, a cytoplasmic signaling molecule that mediates effects of insulin, insulin-like growth factor 1, and other cytokines by acting as a molecular adapto...

Pfam Domains

PHaa 31–144UCSCPH domain
IRSaa 200–295UCSCPTB domain (IRS-1 type)

Gene Aliases

HGNC Name

insulin receptor substrate 2

Papers
RefSeq ID
Protein change
DNA change
Selected Variant
1 paper
NM_003749.3
p.S449W
c.1346C>G
Surrounding Variants
1 paper
NM_003749.3
p.S450P
c.1348T>C
1 paper
NM_003749.3
p.S451N
c.1352G>A
1 paper
NM_003749.3
p.T443S
c.1328C>G
1 paper
NM_003749.3
p.T443S
c.1327A>T
1 paper
NM_003749.3
p.S456W
c.1367C>G
1 paper
NM_003749.3
p.P460L
c.1379C>T
1 paper
NM_003749.3
p.H437Q
c.1311C>G
1 paper
NM_003749.3
p.H437Q
c.1311C>A
1 paper
NM_003749.3
p.P434L
c.1301C>T
1 paper
NM_003749.3
p.G464insFs
c.1392dupC
1 paper
NM_003749.3
p.M431T
c.1292T>C
2 papers
NM_003749.3
p.P468R
c.1403C>G
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